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Neoplasms > Neoplastic Syndromes, Hereditary > Multiple Endocrine Neoplasia > Multiple Endocrine Neoplasia Type 2a
Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Genetic Diseases, Inborn > Neoplastic Syndromes, Hereditary > Multiple Endocrine Neoplasia > Multiple Endocrine Neoplasia Type 2a
Neoplasms > Neoplasms, Multiple Primary > Multiple Endocrine Neoplasia > Multiple Endocrine Neoplasia Type 2a
Neoplasms > Neoplasms by Site > Endocrine Gland Neoplasms > Multiple Endocrine Neoplasia > Multiple Endocrine Neoplasia Type 2a
Endocrine System Diseases > Endocrine Gland Neoplasms > Multiple Endocrine Neoplasia > Multiple Endocrine Neoplasia Type 2a

Preferred term

Multiple Endocrine Neoplasia Type 2a  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • MEA 2a
  • MEA II
  • MEA IIa
  • MEN 2
  • MEN 2a
  • MEN2a
  • MEN 2A Syndrome
  • MEN-2A Syndrome
  • MEN-2A Syndromes
  • MEN II
  • MEN IIa
  • Multiple Endocrine Neoplasia Type 2
  • Multiple Endocrine Neoplasia, Type IIa
  • Multiple Endocrine Neoplasms Type 2a
  • Neoplasia, Multiple Endocrine Type 2a
  • Neoplasms, Multiple Endocrine Type 2a
  • Pheochromocytoma And Amyloid Producing Medullary Thyroid Carcinoma
  • Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma
  • Sipple Syndrome

Note

  • coordinate IM with specific endocrine/neoplasm pre-coordinates (IM) + specific histological type (IM) if pertinent

Scope note

  • A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease.

History note

  • 95; MEA II, MEN II, & SIPPLE SYNDROME were see NEOPLASMS, MULTIPLE ENDOCRINE 1983-94

In other languages

  • MEN 2A -oireyhtymä

    Finnish

  • MEN 2a
  • MEN 2A
  • MEN 2a -oireyhtymä
  • MEN 2a -syndrooma
  • MEN 2A -syndrooma
  • MEN-2a
  • MEN-2A
  • MEN2a
  • monikasvainoireyhtymä 2a
  • monikasvainoireyhtymä 2A
  • multippeli endokriininen neoplasia tyyppi 2a
  • multippeli endokriininen neoplasia tyyppi 2A
  • Multipla hormonella tumörer typ 2a

    Swedish

  • Multipel endokrin neoplasi typ 2a

URI

http://www.yso.fi/onto/mesh/D018813

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