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Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Insulin-Like Growth Factor Binding Proteins > Insulin-Like Growth Factor Binding Protein 1

Preferred term

Insulin-Like Growth Factor Binding Protein 1  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • IGF Binding Protein 1
  • IGF-Binding Protein 1
  • IGFBP-1

Scope note

  • One of the six homologous proteins that specifically bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions. The function of this protein is not completely defined. However, several studies demonstrate that it inhibits IGF binding to cell surface receptors and thereby inhibits IGF-mediated mitogenic and cell metabolic actions. (Proc Soc Exp Biol Med 1993;204(1):4-29)

History note

  • 2005(1992)

In other languages

URI

http://www.yso.fi/onto/mesh/D018970

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