Concept information
Preferred term
Platelet Glycoprotein GPIb-IX Complex
Type
-
Topical Descriptor
Broader concept
Entry terms
- Glycoprotein Ib IX Complex
- Glycoprotein Ib-IX Complex
Scope note
- Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome.
History note
- 96; PLATELET MEMBRANE GLYCOPROTEIN IB was see PLATELET MEMBRANE GLYCOPROTEINS 1987-95
In other languages
-
Finnish
-
trombosyyttien glykoproteiini-GPIb-IX-kompleksi
-
Swedish
URI
http://www.yso.fi/onto/mesh/D019038
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