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... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Receptors, Immunologic > Integrins > Receptors, Cytoadhesin > Platelet Glycoprotein GPIIb-IIIa Complex
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Membrane Glycoproteins > Platelet Membrane Glycoproteins > Platelet Glycoprotein GPIIb-IIIa Complex
... > Carbohydrates > Glycoconjugates > Glycoproteins > Membrane Glycoproteins > Platelet Membrane Glycoproteins > Platelet Glycoprotein GPIIb-IIIa Complex
... > Amino Acids, Peptides, and Proteins > Proteins > Glycoproteins > Membrane Glycoproteins > Platelet Membrane Glycoproteins > Platelet Glycoprotein GPIIb-IIIa Complex
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Receptors, Immunologic > Platelet Membrane Glycoproteins > Platelet Glycoprotein GPIIb-IIIa Complex

Preferred term

Platelet Glycoprotein GPIIb-IIIa Complex  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • alphaIIbbeta3, Integrin
  • beta-3, Integrin alpha-IIb
  • Glycoproteins IIb IIIa
  • Glycoproteins IIb-IIIa
  • GPIIb IIIa Receptors
  • GPIIb-IIIa Receptors
  • Integrin alpha IIb beta 3
  • Integrin alpha-IIb beta-3
  • Integrin alphaIIbbeta3
  • Receptors, GPIIb-IIIa

Scope note

  • Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.

History note

  • 1996(1987); use INTEGRIN ALPHAIIBBETA3 (NM) 1992-1995

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URI

http://www.yso.fi/onto/mesh/D019039

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