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... > Amino Acids, Peptides, and Proteins > Amino Acids > Amino Acids, Sulfur > Methionine > Methionine Sulfoximine > Buthionine Sulfoximine
... > Inorganic Chemicals > Sulfur Compounds > Amino Acids, Sulfur > Methionine > Methionine Sulfoximine > Buthionine Sulfoximine
... > Organic Chemicals > Sulfur Compounds > Amino Acids, Sulfur > Methionine > Methionine Sulfoximine > Buthionine Sulfoximine
... > Amino Acids, Peptides, and Proteins > Amino Acids > Amino Acids, Essential > Methionine > Methionine Sulfoximine > Buthionine Sulfoximine
... > Amino Acids, Peptides, and Proteins > Amino Acids > Amino Acids, Neutral > Methionine > Methionine Sulfoximine > Buthionine Sulfoximine

Preferred term

Buthionine Sulfoximine  

Type

  • Topical Descriptor

Broader concept

Scope note

  • A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)

History note

  • 97: was BUTHIONINE SULFOXIMINE (NM) 1979-96

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URI

http://www.yso.fi/onto/mesh/D019328

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RDF/XML TURTLE JSON-LD Created 6/10/96, last modified 6/30/05