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... > Eukaryota > Animals > Animal Population Groups > Animals, Laboratory > Animals, Inbred Strains > Mice, Inbred Strains > Mice, Inbred MRL lpr
... > Eukaryota > Animals > Chordata > Vertebrates > Mammals > Eutheria > Rodentia > Muridae > Murinae > Mice > Mice, Inbred Strains > Mice, Inbred MRL lpr

Preferred term

Mice, Inbred MRL lpr  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Mice, MRL lpr
  • Mouse, Inbred MRL lpr
  • Mouse, MRL lpr
  • MRL lpr Mice
  • MRL lpr Mouse

Note

  • NIM with no qualifiers when experimental animal

Scope note

  • A mouse substrain that is genetically predisposed to the development of systemic lupus erythematosus-like syndrome, which has been found to be clinically similar to the human disease. It has been determined that this mouse strain carries a mutation in the fas gene. Also, the MRL/lpr is a useful model to study behavioral and cognitive deficits found in autoimmune diseases and the efficacy of immunosuppressive agents.

History note

  • 97

In other languages

URI

http://www.yso.fi/onto/mesh/D019463

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RDF/XML TURTLE JSON-LD Created 6/19/96, last modified 9/2/20