Concept information
Preferred term
Disintegrins
Type
-
Topical Descriptor
Broader concept
Entry terms
- Disintegrin
Note
- polypeptides from snake venom; platelet aggregation inhib
Scope note
- A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors.
History note
- 97; was DISINTEGRINS (NM) 1992-96
In other languages
-
Finnish
-
disintegriini
-
Swedish
URI
http://www.yso.fi/onto/mesh/D019483
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