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Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Membrane Glycoproteins > Thrombospondins
Carbohydrates > Glycoconjugates > Glycoproteins > Membrane Glycoproteins > Thrombospondins
Amino Acids, Peptides, and Proteins > Proteins > Glycoproteins > Membrane Glycoproteins > Thrombospondins

Preferred term

Thrombospondins  

Type

  • Topical Descriptor

Broader concept

Narrower concepts

Entry terms

  • Thrombospondin

Note

  • membrane glycoproteins; THROMBOSPONDIN 1 is also available

Scope note

  • A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.

History note

  • 98; see THROMBOSPONDINS (NM) 1981-97

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URI

http://www.yso.fi/onto/mesh/D019699

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RDF/XML TURTLE JSON-LD Created 6/20/97, last modified 3/16/23