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Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Phosphoprotein Phosphatases > Calcineurin
Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Phosphoprotein Phosphatases > Calcineurin
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Esterases > Phosphoric Monoester Hydrolases > Phosphoprotein Phosphatases > Calcineurin

Preferred term

Calcineurin  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Phosphatase 3, Protein
  • Protein Phosphatase 2B
  • Protein Phosphatase-2B
  • Protein Phosphatase 3

Scope note

  • A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.

History note

  • 98; see CALCINEURIN (NM) 1987-97

In other languages

URI

http://www.yso.fi/onto/mesh/D019703

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RDF/XML TURTLE JSON-LD Created 6/20/97, last modified 5/20/21