Concept information
Preferred term
Tissue Inhibitor of Metalloproteinases
Type
-
Topical Descriptor
Broader concept
Narrower concepts
Entry terms
- Metalloproteinase Tissue Inhibitor
- Proteins, TIMP
- TIMP Proteins
- Tissue Inhibitor of Metalloproteinase
Note
- general or unspecified; prefer specifics
Scope note
- A family of secreted protease inhibitory proteins that regulates the activity of SECRETED MATRIX METALLOENDOPEPTIDASES. They play an important role in modulating the proteolysis of EXTRACELLULAR MATRIX, most notably during tissue remodeling and inflammatory processes.
History note
- 98; see TISSUE INHIBITOR OF METALLOPROTEINASES (NM) 1980-97
In other languages
-
Finnish
-
metalloproteinaasien kudosestäjät
-
TIMP
-
Swedish
URI
http://www.yso.fi/onto/mesh/D019714
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