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Amino Acids, Peptides, and Proteins > Proteins > Proteinase Inhibitory Proteins, Secretory > Tissue Inhibitor of Metalloproteinases > Tissue Inhibitor of Metalloproteinase-2
Amino Acids, Peptides, and Proteins > Peptides > Proteinase Inhibitory Proteins, Secretory > Tissue Inhibitor of Metalloproteinases > Tissue Inhibitor of Metalloproteinase-2

Preferred term

Tissue Inhibitor of Metalloproteinase-2  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • TIMP-2

Scope note

  • A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo.

History note

  • 1998; see TISSUE INHIBITOR OF METALLOPROTEINASE-2 (NM) 1989-1997

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URI

http://www.yso.fi/onto/mesh/D019716

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RDF/XML TURTLE JSON-LD Created 6/30/97, last modified 7/12/22