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Metabolism > RNA Processing, Post-Transcriptional > RNA Splicing > Trans-Splicing
Genetic Phenomena > Gene Expression Regulation > RNA Processing, Post-Transcriptional > RNA Splicing > Trans-Splicing
Chemical Phenomena > Biochemical Phenomena > RNA Processing, Post-Transcriptional > RNA Splicing > Trans-Splicing

Preferred term

Trans-Splicing  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • RNA Splicing, Trans
  • RNA Trans Splicing
  • RNA Trans-Splicing
  • Splicing, Trans
  • Trans RNA Splicing
  • Trans Splicing
  • Trans-Splicings, RNA

Note

  • note category: a physiol process taking place within the cell nucleus; do not confuse with DNA, RECOMBINANT; CLONING, MOLECULAR; or GENETIC ENGINEERING

Scope note

  • The joining of RNA from two different genes. One type of trans-splicing is the "spliced leader" type (primarily found in protozoans such as trypanosomes and in lower invertebrates such as nematodes) which results in the addition of a capped, noncoding, spliced leader sequence to the 5' end of mRNAs. Another type of trans-splicing is the "discontinuous group II introns" type (found in plant/algal chloroplasts and plant mitochondria) which results in the joining of two independently transcribed coding sequences. Both are mechanistically similar to conventional nuclear pre-mRNA cis-splicing. Mammalian cells are also capable of trans-splicing.

History note

  • 99

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URI

http://www.yso.fi/onto/mesh/D020040

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