Concept information
Preferred term
In Situ Nick-End Labeling
Type
-
Topical Descriptor
Broader concept
Entry terms
- In Situ Nick End Labeling
- In Situ Nick End-Labeling
- In Situ Nick End Labelling
- In Situ Nick End-Labelling
- In Situ Nick-End Labelling
- Nick End Labeling, In Situ
- Nick End-Labeling, In Situ
- Nick-End Labeling, In Situ
- Nick End Labelling, In Situ
- Nick End-Labelling, In Situ
- Nick-End Labelling, In Situ
- TUNEL
Scope note
- An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.
History note
- 99
In other languages
-
Finnish
-
Swedish
URI
http://www.yso.fi/onto/mesh/D020287
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