Concept information
Preferred term
MAP Kinase Signaling System
Type
-
Topical Descriptor
Broader concept
Entry terms
- Cascade, MAP Kinase
- ERK1 2 Pathway
- ERK1-2 Pathway
- ERK1-2 Pathways
- ERK Signal Tranduction Pathway
- JNK Pathway
- JNK Pathways
- Kinase Cascade, MAP
- Kinase Pathway, p38
- Kinase Pathways, p38
- MAP Kinase Cascade
- MAP Kinase Cascades
- MAP Kinase Signaling Pathways
- MEK ERK Pathway
- MEK-ERK Pathway
- MEK-ERK Pathways
- p38 Kinase Pathway
- p38 Kinase Pathways
- Pathway, ERK1-2
- Pathway, JNK
- Pathway, MEK-ERK
- Pathway, p38 Kinase
- Pathways, ERK1-2
- Pathways, JNK
- Pathways, MEK-ERK
- Pathways, p38 Kinase
Scope note
- An intracellular signaling system involving the mitogen-activated protein kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
History note
- 2000
In other languages
-
Finnish
-
MAP-kinaasikaskadi
-
Swedish
URI
http://www.yso.fi/onto/mesh/D020935
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