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... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Exopeptidases > Carboxypeptidases > Carboxypeptidase B2
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Exopeptidases > Metalloexopeptidases > Carboxypeptidase B2
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Metalloproteases > Metalloexopeptidases > Carboxypeptidase B2
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Proprotein Convertases > Carboxypeptidase B2

Preferred term

Carboxypeptidase B2  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Arginine Carboxypeptidase
  • Carboxypeptidase B2, Plasma
  • Carboxypeptidase R
  • Carboxypeptidase U
  • Plasma Carboxypeptidase B2
  • Thrombin Activatable Fibrinolysis Inhibitor
  • Thrombin-Activatable Fibrinolysis Inhibitor
  • Thrombin-Activatable Fibrinolysis Inhibitor (TAFI)

Scope note

  • A carboxypeptidase that removes C-terminal lysine or arginine from peptides and proteins. Carboxypeptidase B2 (CPB2) is released into the circulation as a proenzyme which is activated by the THROMBIN-THROMBOMODULIN complex. Activated CPB2 is involved in modulating a variety of processes by cleaving and inactivating various circulating proteins and peptides that are its substrates including FIBRIN; KININS; and ANAPHYLATOXINS.

History note

  • 2015 (2002); use CARBOXYPEPTIDASE U (NM) 1994-2001 and LYSINE CARBOXYPEPTIDASE 1997-2001

In other languages

URI

http://www.yso.fi/onto/mesh/D025901

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