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Amino Acids, Peptides, and Proteins > Proteins > Nuclear Proteins > Karyopherins > alpha Karyopherins
... > Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Membrane Transport Proteins > Nucleocytoplasmic Transport Proteins > Karyopherins > alpha Karyopherins
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Membrane Transport Proteins > Nucleocytoplasmic Transport Proteins > Karyopherins > alpha Karyopherins

Preferred term

alpha Karyopherins  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • Importin-alpha
  • Karyopherin alpha
  • NLS-Binding Protein
  • NLSBP
  • NLS Receptor
  • Nuclear Localization Sequence Receptor
  • Nuclear Localization Signal-Binding Protein
  • receptor, NLS

Scope note

  • Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNALS of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.

History note

  • 2002; use ALPHA KARYOPHERINS (NM) 1994-2001; for IMPORTIN-ALPHA use KARYOPHERINS 1995-2001; for NLS-BINDING PROTEIN, NLSBP & NUCLEAR LOCALIZATION SIGNAL-BINDING PROTEIN use NOPP140 (NM) 1992-2001

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URI

http://www.yso.fi/onto/mesh/D028901

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