Concept information
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Carrier Proteins
RNA-Binding Proteins
RNA Recognition Motif Proteins
Heterogeneous-Nuclear Ribonucleoproteins
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Nucleoproteins
RNA-Binding Proteins
RNA Recognition Motif Proteins
Heterogeneous-Nuclear Ribonucleoproteins
Preferred term
Heterogeneous-Nuclear Ribonucleoprotein K
Type
-
Topical Descriptor
Broader concept
Entry terms
- hnRNP K
Note
- see SCR for specific hnRNP entries
Scope note
- A heterogeneous-nuclear ribonucleoprotein found in the CELL NUCLEUS and the CYTOPLASM. Heterogeneous-nuclear ribonucleoprotein K has been implicated in the regulation of gene expression at nearly all levels: GENETIC TRANSCRIPTION; mRNA processing (RNA PROCESSING, POST-TRANSCRIPTIONAL), mRNA transport, mRNA stability, and translation (TRANSLATION, GENETIC). The hnRNP protein has a strong affinity for polypyrimidine-rich RNA and for single-stranded polypyrimidine-rich DNA. Multiple hnRNP K protein isoforms exist due to alternative splicing and display different nucleic-acid-binding properties.
History note
- 2003; use HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K (NM) 1994-2002; for HNRNP K use HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS (NM) 1994-2002
In other languages
URI
http://www.yso.fi/onto/mesh/D034641
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