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... > Amino Acids, Peptides, and Proteins > Proteins > Neoplasm Proteins > Oncogene Proteins > Proto-Oncogene Proteins > RNA-Binding Protein FUS
... > Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > RNA-Binding Proteins > RNA Recognition Motif Proteins > Heterogeneous-Nuclear Ribonucleoproteins > RNA-Binding Protein FUS
... > Amino Acids, Peptides, and Proteins > Proteins > Nucleoproteins > RNA-Binding Proteins > RNA Recognition Motif Proteins > Heterogeneous-Nuclear Ribonucleoproteins > RNA-Binding Protein FUS
... > Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > RNA-Binding Proteins > Ribonucleoproteins > Heterogeneous-Nuclear Ribonucleoproteins > RNA-Binding Protein FUS
... > Amino Acids, Peptides, and Proteins > Proteins > Nucleoproteins > RNA-Binding Proteins > Ribonucleoproteins > Heterogeneous-Nuclear Ribonucleoproteins > RNA-Binding Protein FUS

Preferred term

RNA-Binding Protein FUS  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Fusion Protein in Myxoid Liposarcoma
  • FUS Protein
  • FUS RNA Binding Protein
  • FUS RNA-Binding Protein
  • hnRNP P2
  • POMp75 Protein
  • RNA-Binding Protein, FUS
  • TLS Protein
  • Translocated in Liposarcoma Protein

Scope note

  • A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator, while the C terminus is required for RNA binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS, FUSION) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (LIPOSARCOMA, MYXOID) and acute myeloid leukemia.

History note

  • 2003; for FUS PROTEIN & HNRNP P2 use HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS (NM) 1996-2002; for TLS PROTEIN use HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS (NM) 1993-2002;

In other languages

URI

http://www.yso.fi/onto/mesh/D034702

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