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Nucleic Acids, Nucleotides, and Nucleosides > Nucleic Acids > RNA > RNA, Antisense > RNA, Small Interfering
... > Nucleic Acids, Nucleotides, and Nucleosides > Nucleic Acids > Nucleic Acid Probes > Antisense Elements (Genetics) > RNA, Antisense > RNA, Small Interfering
... > Chemical Actions and Uses > Specialty Uses of Chemicals > Laboratory Chemicals > Molecular Probes > Nucleic Acid Probes > Antisense Elements (Genetics) > RNA, Antisense > RNA, Small Interfering
... > Chemical Actions and Uses > Pharmacologic Actions > Diagnostic Uses of Chemicals > Molecular Probes > Nucleic Acid Probes > Antisense Elements (Genetics) > RNA, Antisense > RNA, Small Interfering
... > Nucleic Acids, Nucleotides, and Nucleosides > Nucleic Acids > RNA > RNA, Untranslated > RNA, Small Untranslated > RNA, Small Interfering

Preferred term

RNA, Small Interfering  

Type

  • Topical Descriptor

Broader concept

Narrower concepts

Related concepts

Entry terms

  • Interfering RNA, Short
  • RNA, Short Interfering
  • Short Interfering RNA
  • siRNA
  • Small Interfering RNA

Note

  • Do not confuse with defective interfering RNA (diRNA), a viral RNA of DEFECTIVE VIRUSES.

Scope note

  • Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.

History note

  • 2003; use RNA, SMALL INTERFERING (NM) 2001-2002

In other languages

URI

http://www.yso.fi/onto/mesh/D034741

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