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... > Enzymes and Coenzymes > Enzymes > Hydrolases > Esterases > Ribonucleases > Endoribonucleases > RNA-Induced Silencing Complex
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Esterases > Endonucleases > Endoribonucleases > RNA-Induced Silencing Complex
... > Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > RNA-Binding Proteins > Ribonucleoproteins > RNA-Induced Silencing Complex
... > Amino Acids, Peptides, and Proteins > Proteins > Nucleoproteins > RNA-Binding Proteins > Ribonucleoproteins > RNA-Induced Silencing Complex

Preferred term

RNA-Induced Silencing Complex  

Type

  • Topical Descriptor

Broader concept

Narrower concepts

Related concepts

Entry terms

  • Multicomponent Nuclease, RISC
  • Nuclease, RISC Multicomponent
  • RISC Multicomponent Nuclease

Scope note

  • A multicomponent, ribonucleoprotein complex comprised of one of the family of ARGONAUTE PROTEINS and the "guide strand" of the one of the 20- to 30-nucleotide small RNAs. RISC cleaves specific RNAs, which are targeted for degradation by homology to these small RNAs. Functions in regulating gene expression are determined by the specific argonaute protein and small RNA including siRNA (RNA, SMALL INTERFERING), miRNA (MICRORNA), or piRNA (PIWI-INTERACTING RNA).

History note

  • 2003; use RNA-INDUCED SILENCING COMPLEX (NM) 2001-2002

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URI

http://www.yso.fi/onto/mesh/D034743

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