Concept information
Preferred term
Complement Pathway, Mannose-Binding Lectin
Type
-
Topical Descriptor
Broader concept
Entry terms
- Lectin Complement Pathway
- Lectin-Complement Pathway
- Lectin-Complement Pathways
- Lectin Pathway, Mannan-Binding (Complement Activation)
- Lectin Pathways, Mannan-Binding (Complement Activation)
- Mannan Binding Lectin Complement Pathway
- Mannan-Binding Lectin Complement Pathway
- Mannan Binding Lectin Pathway (Complement Activation)
- Mannan-Binding Lectin Pathway (Complement Activation)
- Mannan-Binding Lectin Pathways (Complement Activation)
- Mannose Binding Lectin Complement Pathway
- Mannose-Binding Lectin Complement Pathway
- Pathway, Lectin-Complement
- Pathway, Mannan-Binding Lectin (Complement Activation)
- Pathways, Lectin-Complement
- Pathways, Mannan-Binding Lectin (Complement Activation)
Scope note
- Complement activation triggered by the interaction of microbial POLYSACCHARIDES with serum MANNOSE-BINDING LECTIN resulting in the activation of MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES. As in the classical pathway, MASPs cleave COMPLEMENT C4 and COMPLEMENT C2 to form C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
History note
- 2003
In other languages
URI
http://www.yso.fi/onto/mesh/D037582
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