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Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Sirtuins
Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Sirtuins
... > Enzymes and Coenzymes > Enzymes > Transferases > Glycosyltransferases > Pentosyltransferases > ADP Ribose Transferases > Sirtuins
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Amidohydrolases > Histone Deacetylases > Group III Histone Deacetylases > Sirtuins

Preferred term

Sirtuins  

Type

  • Topical Descriptor

Broader concept

Narrower concepts

Related concepts

Entry terms

  • Silent Mating Type Information Regulator 2 like Proteins
  • Silent Mating Type Information Regulator 2-like Proteins
  • Sir2 like Proteins
  • Sir2-like Proteins
  • SIRT
  • SIRTs
  • Sirtuin

Scope note

  • A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities.

History note

  • 2003

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URI

http://www.yso.fi/onto/mesh/D037761

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