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Amino Acids, Peptides, and Proteins > Proteins > Nuclear Proteins > Silent Information Regulator Proteins, Saccharomyces cerevisiae
Amino Acids, Peptides, and Proteins > Proteins > Fungal Proteins > Saccharomyces cerevisiae Proteins > Silent Information Regulator Proteins, Saccharomyces cerevisiae

Preferred term

Silent Information Regulator Proteins, Saccharomyces cerevisiae  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • Silent Information Regulator Proteins, S cerevisiae
  • SIR Proteins, S cerevisiae

Scope note

  • A set of nuclear proteins in SACCHAROMYCES CEREVISIAE that are required for the transcriptional repression of the silent mating type loci. They mediate the formation of silenced CHROMATIN and repress both transcription and recombination at other loci as well. They are comprised of 4 non-homologous, interacting proteins, Sir1p, Sir2p, Sir3p, and Sir4p. Sir2p, an NAD-dependent HISTONE DEACETYLASE, is the founding member of the family of SIRTUINS.

History note

  • 2003

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URI

http://www.yso.fi/onto/mesh/D038281

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