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... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Receptors, Collagen > Integrin alpha2beta1
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Receptors, Immunologic > Receptors, Laminin > Integrin alpha2beta1
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Membrane Glycoproteins > Platelet Membrane Glycoproteins > Integrin alpha2beta1
... > Carbohydrates > Glycoconjugates > Glycoproteins > Membrane Glycoproteins > Platelet Membrane Glycoproteins > Integrin alpha2beta1
... > Amino Acids, Peptides, and Proteins > Proteins > Glycoproteins > Membrane Glycoproteins > Platelet Membrane Glycoproteins > Integrin alpha2beta1
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Receptors, Immunologic > Platelet Membrane Glycoproteins > Integrin alpha2beta1
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Receptors, Immunologic > Integrins > Receptors, Very Late Antigen > Integrin alpha2beta1
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Receptors, Immunologic > Integrins > Receptors, Fibronectin > Integrin alpha2beta1

Preferred term

Integrin alpha2beta1  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • alpha2beta1Integrin
  • CD49b CD29
  • CD49b-CD29
  • Glycoprotein Ia IIa
  • Glycoprotein Ia-IIa
  • Late Antigen-2, Very
  • Platelet Membrane Glycoprotein Heterodimer Ia IIa
  • Platelet Membrane Glycoprotein Heterodimer Ia-IIa
  • Very Late Antigen 2
  • Very Late Antigen-2
  • VLA 2
  • VLA-2

Scope note

  • An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.

History note

  • 2003; for VLA-2 use COLLAGEN RECEPTORS (NM) 1991-2002; for PLATELET MEMBRANE GLYCOPROTEIN HETERODIMER IA-IIA use COLLAGEN RECEPTORS (NM) 1992-2000; for INTEGRIN ALPHA2BETA1 & CD49B-CD29 use COLLAGEN RECEPTORS (NM) 1994-2002; for ALPHA2BETA1INTEGRIN use COLLAGEN RECEPTORS (NM) 2001-2002

In other languages

URI

http://www.yso.fi/onto/mesh/D038982

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