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... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Receptors, Immunologic > Integrins > Integrin alpha Chains

Preferred term

Integrin alpha Chains  

Type

  • Topical Descriptor

Broader concept

Narrower concepts

Entry terms

  • alpha Integrins
  • Integrin alpha Subunits
  • Integrins, alpha

Scope note

  • The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.

History note

  • 2003

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URI

http://www.yso.fi/onto/mesh/D039001

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