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... > Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > RNA-Binding Proteins > Poly(A)-Binding Proteins > Poly(A)-Binding Protein II
... > Amino Acids, Peptides, and Proteins > Proteins > Nucleoproteins > RNA-Binding Proteins > Poly(A)-Binding Proteins > Poly(A)-Binding Protein II

Preferred term

Poly(A)-Binding Protein II  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • PAB2 Poly(A) Binding Protein
  • PAB II
  • PABP2
  • Pabp2 Gene Product
  • Pabp2 Protein
  • Poly(A) Binding Protein II
  • Poly(A) Binding Protein, Nuclear 1

Scope note

  • A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY, OCULOPHARYNGEAL.

History note

  • 2003; for PAB II use POLY(A)-BINDING PROTEINS (NM) 1995-2002; for PABP2 GENE PRODUCT & PABP2 PROTEIN use POLY(A)-BINDING PROTEINS (NM) 1999-2002; for PABP2 use POLY(A)-BINDING PROTEINS (NM) 2000-2002

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URI

http://www.yso.fi/onto/mesh/D039103

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