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... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Receptors, Immunologic > Receptors, Laminin > Integrin alpha6beta1
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Membrane Glycoproteins > Platelet Membrane Glycoproteins > Integrin alpha6beta1
... > Carbohydrates > Glycoconjugates > Glycoproteins > Membrane Glycoproteins > Platelet Membrane Glycoproteins > Integrin alpha6beta1
... > Amino Acids, Peptides, and Proteins > Proteins > Glycoproteins > Membrane Glycoproteins > Platelet Membrane Glycoproteins > Integrin alpha6beta1
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Receptors, Immunologic > Platelet Membrane Glycoproteins > Integrin alpha6beta1
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Receptors, Immunologic > Integrins > Receptors, Very Late Antigen > Integrin alpha6beta1

Preferred term

Integrin alpha6beta1  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • alpha 6 beta 1 Integrin
  • alpha6beta1 Integrin
  • CD49f CD29
  • CD49f-CD29
  • Glycoprotein I'c-IIa, Platelet
  • I'c-IIa, Platelet Glycoprotein
  • Integrin alpha(6)beta(1)
  • Integrin, alpha6beta1
  • Platelet Glycoprotein I'c IIa
  • Platelet Glycoprotein I'c-IIa
  • VLA 6
  • VLA-6

Scope note

  • A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.

History note

  • 2003; use INTEGRIN ALPHA6BETA1 (NM) 1992-2002

In other languages

URI

http://www.yso.fi/onto/mesh/D039121

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