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... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Receptors, Collagen > Integrin alpha1beta1
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Receptors, Immunologic > Receptors, Laminin > Integrin alpha1beta1
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Receptors, Immunologic > Integrins > Receptors, Very Late Antigen > Integrin alpha1beta1

Preferred term

Integrin alpha1beta1  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • alpha1beta1 Integrin
  • CD49a-CD29
  • Integrin alpha(1)beta(1)
  • Integrin, alpha1beta1
  • VLA-1

Scope note

  • Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.

History note

  • 2003; use INTEGRIN ALPHA1BETA1 (NM) 1994-2002

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URI

http://www.yso.fi/onto/mesh/D039222

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