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... > Biological Factors > Antigens > Antigens, Surface > Cell Adhesion Molecules > Cell Adhesion Molecules, Neuronal > Neural Cell Adhesion Molecules > Neural Cell Adhesion Molecule L1
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Membrane Glycoproteins > Cell Adhesion Molecules > Cell Adhesion Molecules, Neuronal > Neural Cell Adhesion Molecules > Neural Cell Adhesion Molecule L1
... > Carbohydrates > Glycoconjugates > Glycoproteins > Membrane Glycoproteins > Cell Adhesion Molecules > Cell Adhesion Molecules, Neuronal > Neural Cell Adhesion Molecules > Neural Cell Adhesion Molecule L1
... > Amino Acids, Peptides, and Proteins > Proteins > Glycoproteins > Membrane Glycoproteins > Cell Adhesion Molecules > Cell Adhesion Molecules, Neuronal > Neural Cell Adhesion Molecules > Neural Cell Adhesion Molecule L1

Preferred term

Neural Cell Adhesion Molecule L1  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • CALL Protein
  • CamL1 Gene Product
  • Cell Adhesion Molecule L1
  • Cell Surface Glycoprotein L1
  • F11 Glycoprotein
  • Glycoprotein, NGF-Inducible
  • Glycoprotein, NILE
  • L1CAM
  • L1 Cell Adhesion Molecule
  • Nerve Growth Factor Inducible Large External Glycoprotein
  • Nerve Growth Factor-Inducible Large External Glycoprotein
  • Neural Adhesion Molecule L1
  • NGF Inducible Glycoprotein
  • NGF-Inducible Glycoprotein
  • NILE Glycoprotein
  • NILE Protein

Scope note

  • A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.

History note

  • 2003; use NEURAL CELL ADHESION MOLECULE L1 (NM) 1983-2002; for NEURAL CELL ADHESION MOLECULE L1; F11 GLYCOPROTEIN; CELL ADHESION MOLECULE L1; CAML1 GENE PRODUCT; CELL SURFACE GLYCOPROTEIN L1; L1 CELL ADHESION MOLECULE; L1 CAM & NEURAL ADHESION MOLECULE L1 use LEUKOCYTE L1 ANTIGEN COMPLEX (NM) 1992-2002; for CALL PROTEIN use LEUKOCYTE L1 ANTIGEN COMPLEX (NM) 1999-2002; for NILE PROTEIN use LEUCKCYTE L1 ANTIGEN COMPLEX (NM) 1996-2002

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URI

http://www.yso.fi/onto/mesh/D039842

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