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... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Neuropilins > Neuropilin-1

Preferred term

Neuropilin-1  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • A5 Antigen
  • Antigen, A5
  • Npn 1 Protein
  • Npn-1 Protein
  • NRP1 Protein
  • Receptor, Sema III
  • Sema III Receptor
  • Semaphorin III Receptor

Scope note

  • A dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL) and AXONAL GUIDANCE. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS 3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with plexins or VEGF RECEPTORS; their binding affinity and specificity are determined by the composition of the neuropilin dimer and the identity of other receptors complexed with it. Neuropilin-1 is expressed in distinct patterns during neural development, complementary to those described for NEUROPILIN-2.

History note

  • 2003; use NEUROPILIN-1 (NM) 1991-2002

In other languages

URI

http://www.yso.fi/onto/mesh/D039942

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