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Concept information

Preferred term

Vascular Endothelial Growth Factor Receptor-1  

Type

  • Topical Descriptor

Entry terms

  • FLT1 Receptor Tyrosine Kinase
  • FLT1 RTK
  • FLT VEGF Receptor
  • fms-Like Tyrosine Kinase
  • Proto Oncogene Protein flt
  • Proto-Oncogene Protein flt
  • Receptor, FLT VEGF
  • Tyrosine Kinase, fms-Like
  • VEGFR-1
  • VEGF Receptor, FLT
  • VEGF Receptor flt 1 Protein
  • VEGF Receptor flt-1 Protein

Scope note

  • A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.

History note

  • 2003; use VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 (NM) 1990-2002; for FLK-1 RECEPTOR TYROSINE KINASE use RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR (NM) 1993-2002

URI

http://www.yso.fi/onto/mesh/D040281

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