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Amino Acids, Peptides, and Proteins > Proteins > Flavoproteins > Cytochrome-B(5) Reductase
... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > NADH, NADPH Oxidoreductases > Cytochrome Reductases > Cytochrome-B(5) Reductase

Preferred term

Cytochrome-B(5) Reductase  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • B5 Reductase, NADH-Cytochrome
  • NADH Cytochrome B5 Reductase
  • NADH-Cytochrome B5 Reductase

Note

  • /defic: consider also METHEMOGLOBINEMIA

Scope note

  • A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.

History note

  • 2004; use CYTOCHROME B(5) REDUCTASE (NM) 1980-2003

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URI

http://www.yso.fi/onto/mesh/D042966

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