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... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Alcohol Oxidoreductases > NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases > 11-beta-Hydroxysteroid Dehydrogenases > 11-beta-Hydroxysteroid Dehydrogenase Type 2
... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Alcohol Oxidoreductases > Hydroxysteroid Dehydrogenases > 11-beta-Hydroxysteroid Dehydrogenases > 11-beta-Hydroxysteroid Dehydrogenase Type 2

Preferred term

11-beta-Hydroxysteroid Dehydrogenase Type 2  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • 11 beta-HSD2
  • 11beta-HSD2
  • 11beta-HSD2 Reductase
  • 11 beta-Hydroxysteroid Dehydrogenase Type 2
  • 11beta Hydroxysteroid Dehydrogenase Type 2
  • 11beta-Hydroxysteroid Dehydrogenase Type 2

Scope note

  • An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.

History note

  • 2004; for 11 BETA-HSD2 use 11 BETA-HYDROXYSTEROID DEHYDROGENASES (NM) 1992-2003

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URI

http://www.yso.fi/onto/mesh/D043209

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