Concept information
Preferred term
alpha-Mannosidase
Type
-
Topical Descriptor
Broader concept
Entry terms
- alpha D Mannosidase
- alpha-D-Mannosidase
- alpha D Mannoside Mannohydrolase
- alpha-D-Mannoside Mannohydrolase
- alpha-Mannosidase, Neutral
- Mannohydrolase, alpha-D-Mannoside
- Neutral alpha Mannosidase
- Neutral alpha-Mannosidase
Note
- /DEFIC: consider also ALPHA-MANNOSIDOSIS
Scope note
- An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.
History note
- 2004; use ALPHA-MANNOSIDASE (NM) 1980-2003
In other languages
-
Finnish
-
Swedish
URI
http://www.yso.fi/onto/mesh/D043323
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