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Enzymes and Coenzymes > Enzymes > Ligases > Ubiquitin-Protein Ligase Complexes

Preferred term

Ubiquitin-Protein Ligase Complexes  

Type

  • Topical Descriptor

Broader concept

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Note

  • UBIQUITIN-PROTEIN LIGASES is also available

Scope note

  • Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming a peptide bond between the C-terminal GLYCINE of UBIQUITIN and the alpha-amino groups of LYSINE residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal proteins. The complex of enzymes can be broken down into three components that involve activation of ubiquitin (UBIQUITIN-ACTIVATING ENZYMES), conjugation of ubiquitin to the ligase complex (UBIQUITIN-CONJUGATING ENZYMES), and ligation of ubiquitin to the substrate protein (UBIQUITIN-PROTEIN LIGASES).

History note

  • 2004

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URI

http://www.yso.fi/onto/mesh/D043743

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