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... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Receptors, G-Protein-Coupled > Receptor, PAR-2
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Receptors, Proteinase-Activated > Receptor, PAR-2

Preferred term

Receptor, PAR-2  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • PAR 2 Receptor
  • PAR-2 Receptor
  • PAR2 Receptor
  • Protease Activated Receptor 2
  • Protease-Activated Receptor 2
  • Proteinase Activated Receptor 2
  • Receptor 2, Protease-Activated
  • Receptor, PAR2
  • Receptors, Trypsin
  • Receptor, Trypsin
  • Trypsin Receptor
  • Trypsin Receptors

Scope note

  • A G-protein-coupled, proteinase-activated receptor that is expressed in a variety of tissues including ENDOTHELIUM; LEUKOCYTES; and the GASTROINTESTINAL TRACT. The receptor is activated by TRYPSIN, which cleaves off the N-terminal peptide from the receptor. The new N-terminal peptide is a cryptic ligand for the receptor. The uncleaved receptor can also be activated by the N-terminal peptide present on the activated THROMBIN RECEPTOR and by small synthetic peptides that contain the unmasked N-terminal sequence.

History note

  • 2004; use RECEPTOR, PAR-2 (NM) 1994-2003; for TRYPSIN RECEPTOR use RECEPTOR, PAR-2 (NM) 1986-2003

In other languages

URI

http://www.yso.fi/onto/mesh/D044464

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