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... > Enzymes and Coenzymes > Enzymes > Hydrolases > Esterases > Endonucleases > Endodeoxyribonucleases > Flap Endonucleases
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Esterases > Deoxyribonucleases > Endodeoxyribonucleases > Flap Endonucleases

Preferred term

Flap Endonucleases  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Endonuclease, Flap
  • Flap Endonuclease

Scope note

  • Endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap structure occurs in double-stranded DNA containing a single-stranded break where the 5' portion of the downstream strand is too long and overlaps the 3' end of the upstream strand. Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick.

History note

  • 2004; use FLAP ENDONUCLEASES (NM) 1994-2003; for FEN1 PROTEIN use EXODEOXYRIBONUCLEASE V 1997-2003; for RTH-1 NUCLEASE use EXODEOXYRIBONUCLEASE V 1996-2003

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URI

http://www.yso.fi/onto/mesh/D045585

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