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Investigative Techniques > Genetic Techniques > Chromatin Immunoprecipitation
Investigative Techniques > Immunologic Techniques > Immunoprecipitation > Chromatin Immunoprecipitation
Chemical Phenomena > Chemical Precipitation > Immunoprecipitation > Chromatin Immunoprecipitation
Investigative Techniques > Chemistry Techniques, Analytical > Chemical Precipitation > Immunoprecipitation > Chromatin Immunoprecipitation

Preferred term

Chromatin Immunoprecipitation  

Type

  • Topical Descriptor

Broader concept

Narrower concepts

Entry terms

  • Immunoprecipitation, Chromatin

Scope note

  • A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.

History note

  • 2005

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URI

http://www.yso.fi/onto/mesh/D047369

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