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Concept information

Preferred term

Transient Receptor Potential Channels  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Cation Channels, TRP
  • Cation Channel, TRP
  • Channels, TRP Cation
  • Channel, TRP Cation
  • Membrane Proteins, TRP
  • Proteins, TRP Membrane
  • Transient Receptor Potential Cation Channel
  • Transient Receptor Potential Cation Channels
  • Transient Receptor Potential Channel
  • TRP Cation Channel
  • TRP Cation Channels
  • TRP Membrane Proteins

Note

  • note entry terms: TRP refers to transient receptor potential not TRYPTOPHAN

Scope note

  • A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN REPEATS are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.

History note

  • 2006

In other languages

URI

http://www.yso.fi/onto/mesh/D050051

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