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Metabolism > Pharmacokinetics > Biotransformation > Inactivation, Metabolic > Metabolic Detoxication, Phase I
... > Physiological Phenomena > Pharmacological and Toxicological Phenomena > Pharmacokinetics > Biotransformation > Inactivation, Metabolic > Metabolic Detoxication, Phase I

Preferred term

Metabolic Detoxication, Phase I  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • Detoxication, Oxidative Metabolic
  • Detoxications, Oxidative Metabolic
  • Detoxification, Phase I
  • Detoxifications, Phase I
  • Metabolic Detoxication, Oxidative
  • Metabolic Detoxications, Oxidative
  • Metabolic Detoxification, Phase I
  • Oxidative Metabolic Detoxication
  • Oxidative Metabolic Detoxications
  • Phase I Detoxification

Scope note

  • Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.

History note

  • 2006

In other languages

URI

http://www.yso.fi/onto/mesh/D050216

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