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Metabolism > Pharmacokinetics > Biotransformation > Inactivation, Metabolic > Metabolic Detoxication, Phase II
... > Physiological Phenomena > Pharmacological and Toxicological Phenomena > Pharmacokinetics > Biotransformation > Inactivation, Metabolic > Metabolic Detoxication, Phase II

Preferred term

Metabolic Detoxication, Phase II  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • Conjugative Metabolic Detoxication
  • Conjugative Metabolic Detoxications
  • Detoxication, Conjugative Metabolic
  • Detoxications, Conjugative Metabolic
  • Detoxification, Phase II
  • Detoxifications, Phase II
  • Metabolic Detoxication, Conjugative
  • Metabolic Detoxications, Conjugative
  • Metabolic Detoxification, Phase II
  • Phase II Detoxification
  • Phase II Detoxifications

Scope note

  • The conjugation of exogenous substances with various hydrophilic substituents to form water soluble products that are excretable in URINE. Phase II modifications include GLUTATHIONE conjugation; ACYLATION; and AMINATION. Phase II enzymes include GLUTATHIONE TRANSFERASE and GLUCURONOSYLTRANSFERASE. In a sense these reactions detoxify phase I reaction products.

History note

  • 2006

In other languages

URI

http://www.yso.fi/onto/mesh/D050217

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