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... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Oxygenases > Dioxygenases > Homogentisate 1,2-Dioxygenase

Preferred term

Homogentisate 1,2-Dioxygenase  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • Acid Oxidase, Homogentisic
  • Dioxygenase, Homogentisate
  • Homogentisate Dioxygenase
  • Homogentisate Oxidase
  • Homogentisate Oxygenase
  • Homogentisic Acid Oxidase
  • Oxidase, Homogentisate
  • Oxidase, Homogentisic Acid
  • Oxygenase, Homogentisate

Scope note

  • A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5.

History note

  • 2006(1969)

In other languages

URI

http://www.yso.fi/onto/mesh/D050560

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