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Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > NFATC Transcription Factors

Preferred term

NFATC Transcription Factors  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • NFATC Proteins
  • NF AT Proteins
  • NF-AT Proteins
  • NFAT Proteins
  • NF-AT, Transcription Factor
  • Nuclear Factor of Activated T Cells, Cytoplasmic
  • Nuclear Factor of Activated T-Cells, Cytoplasmic
  • Nuclear Factors of Activated T Cells
  • Nuclear Factors of Activated T-Cells
  • Transcription Factor NF AT
  • Transcription Factor NF-AT

Scope note

  • A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.

History note

  • 2006(1993)

In other languages

URI

http://www.yso.fi/onto/mesh/D050778

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