Skip to main content

Medical Subject Headings

Search from vocabulary

Content language

Concept information

Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > STAT Transcription Factors
Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Adaptor Proteins, Signal Transducing > STAT Transcription Factors
Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > STAT Transcription Factors
Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > STAT Transcription Factors

Preferred term

STAT Transcription Factors  

Type

  • Topical Descriptor

Broader concept

Narrower concepts

Entry terms

  • STAT (Signal Transducers and Activators of Transcription) Proteins

Note

  • general; prefer specifics

Scope note

  • A family of transcription factors containing SH2 DOMAINS that are involved in CYTOKINE-mediated SIGNAL TRANSDUCTION. STAT transcription factors are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via PHOSPHORYLATION. Once activated they dimerize and translocate into the CELL NUCLEUS where they influence GENE expression. They play a role in regulating CELL GROWTH PROCESSES and CELL DIFFERENTIATION. STAT transcription factors are inhibited by SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS and PROTEIN INHIBITORS OF ACTIVATED STAT.

History note

  • 2006

In other languages

URI

http://www.yso.fi/onto/mesh/D050791

Download this concept:

RDF/XML TURTLE JSON-LD Created 6/30/05, last modified 2/18/16