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... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Oxidoreductases Acting on CH-NH Group Donors > Oxidoreductases, N-Demethylating > Cytochrome P-450 CYP3A
Enzymes and Coenzymes > Cytochromes > Cytochrome P-450 Enzyme System > Cytochrome P450 Family 3 > Cytochrome P-450 CYP3A
... > Amino Acids, Peptides, and Proteins > Proteins > Hemeproteins > Cytochromes > Cytochrome P-450 Enzyme System > Cytochrome P450 Family 3 > Cytochrome P-450 CYP3A
... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Oxygenases > Mixed Function Oxygenases > Cytochrome P-450 Enzyme System > Cytochrome P450 Family 3 > Cytochrome P-450 CYP3A

Preferred term

Cytochrome P-450 CYP3A  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • CYP3A
  • Cytochrome P450 3A
  • Cytochrome P 450IIIA
  • Cytochrome P-450IIIA
  • Erythromycin N Demethylase
  • Erythromycin N-Demethylase
  • N-Demethylase, Erythromycin
  • P450 3A, Cytochrome
  • P-450IIIA, Cytochrome

Scope note

  • A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.

History note

  • 2006(1980)

In other languages

URI

http://www.yso.fi/onto/mesh/D051544

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