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Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Protein Serine-Threonine Kinases > Proto-Oncogene Proteins c-bcr
Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Protein Serine-Threonine Kinases > Proto-Oncogene Proteins c-bcr
... > Enzymes and Coenzymes > Enzymes > Transferases > Phosphotransferases > Phosphotransferases (Alcohol Group Acceptor) > Protein Kinases > Protein Serine-Threonine Kinases > Proto-Oncogene Proteins c-bcr
... > Amino Acids, Peptides, and Proteins > Proteins > Neoplasm Proteins > Oncogene Proteins > Proto-Oncogene Proteins > Proto-Oncogene Proteins c-bcr
... > Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > GTP-Binding Protein Regulators > Guanine Nucleotide Exchange Factors > Rho Guanine Nucleotide Exchange Factors > Proto-Oncogene Proteins c-bcr
... > Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > GTP-Binding Protein Regulators > Guanine Nucleotide Exchange Factors > Rho Guanine Nucleotide Exchange Factors > Proto-Oncogene Proteins c-bcr

Preferred term

Proto-Oncogene Proteins c-bcr  

Type

  • Topical Descriptor

Broader concept

Narrower concepts

Entry terms

  • bcr Proto Oncogene Proteins
  • bcr Proto-Oncogene Proteins
  • Breakpoint Cluster Region Protein
  • c bcr Proteins
  • c-bcr Proteins
  • c-bcr, Proto-Oncogene Protein
  • c bcr Proto Oncogene Proteins
  • c-bcr Proto-Oncogene Proteins
  • Proto Oncogene Protein bcr
  • Proto-Oncogene Protein bcr
  • Proto Oncogene Protein c bcr
  • Proto-Oncogene Protein c-bcr
  • Proto-Oncogene Proteins, bcr
  • Proto-Oncogene Proteins, c-bcr

Scope note

  • A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.

History note

  • 2006(1988)

In other languages

URI

http://www.yso.fi/onto/mesh/D051562

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