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Concept information

Preferred term

TNF-Related Apoptosis-Inducing Ligand  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Antigen, CD253
  • Apo 2 Ligand
  • Apo-2 Ligand
  • Apo 2L Protein
  • Apo-2L Protein
  • CD253 Antigen
  • TNF Superfamily, Member 10
  • TRAIL Protein
  • Tumor Necrosis Factor Ligand Superfamily Member 10

Scope note

  • A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.

History note

  • 2007(2005)

URI

http://www.yso.fi/onto/mesh/D053221

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