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Concept information

Lipids > Lipoproteins > Apolipoproteins > Apolipoproteins E > Apolipoprotein E4
... > Amino Acids, Peptides, and Proteins > Proteins > Lipoproteins > Apolipoproteins > Apolipoproteins E > Apolipoprotein E4
... > Amino Acids, Peptides, and Proteins > Proteins > Apoproteins > Apolipoproteins > Apolipoproteins E > Apolipoprotein E4

Preferred term

Apolipoprotein E4  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Apo E 4
  • Apo E-4
  • Apo E4
  • ApoE4
  • Apo E epsilon 4
  • Apolipoprotein E 4
  • Apolipoprotein E-4

Scope note

  • A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.

History note

  • 2007 (1982)

In other languages

URI

http://www.yso.fi/onto/mesh/D053327

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