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Lipids > Lipoproteins > Apolipoproteins > Apolipoproteins E > Apolipoprotein E2
... > Amino Acids, Peptides, and Proteins > Proteins > Lipoproteins > Apolipoproteins > Apolipoproteins E > Apolipoprotein E2
... > Amino Acids, Peptides, and Proteins > Proteins > Apoproteins > Apolipoproteins > Apolipoproteins E > Apolipoprotein E2

Preferred term

Apolipoprotein E2  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Apo E 2
  • Apo E-2
  • Apo E2
  • ApoE2
  • APOE epsilon 2
  • APOE epsilon2
  • APOE-epsilon 2
  • APOE-epsilon2
  • Apolipoprotein E 2
  • Apolipoprotein E-2
  • Apolipoprotein E epsilon2
  • Apolipoprotein E-epsilon2

Scope note

  • One of three major isoforms of apolipoprotein E. In humans, Apo E2 differs from APOLIPOPROTEIN E3 at one residue 158 where arginine is replaced by cysteine (R158--C). In contrast to Apo E3, Apo E2 displays extremely low binding affinity for LDL receptors (RECEPTORS, LDL) which mediate the internalization and catabolism of lipoprotein particles in liver cells. ApoE2 allelic homozygosity is associated with HYPERLIPOPROTEINEMIA TYPE III.

History note

  • 2007 (1984)

In other languages

URI

http://www.yso.fi/onto/mesh/D053329

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