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Concept information

Preferred term

Edar-Associated Death Domain Protein  

Type

  • Topical Descriptor

Entry terms

  • Edaradd Protein

Scope note

  • A tumor necrosis factor receptor-associated factor that acts as a specific signaling adaptor protein for the EDAR RECEPTOR and plays an important role in ectodermal development. It binds to edar receptor via its C-terminal death domain region and to other specific TNF receptor-associated factors via its N-terminal domain. Loss of function of edar-associated death domain protein is associated with AUTOSOMAL RECESSIVE ANHIDROTIC ECTODERMAL DYSPLASIA.

History note

  • 2007(2002)

In other languages

URI

http://www.yso.fi/onto/mesh/D053362

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